Endocrine Abstracts

Purpose: Cocaine and amphetamine-regulated transcript (CART) influences the appetite, obesity and pancreatic functions. The aim of this study is to determine the CART level of patients with PCOS and examine the relation with the insulin resistance in patients with PCOS.Methods: 41 patients with PCOS and and 39 healthy women were included in the study whose age and BMI matched. For PCOS diagnosis, 2003 Rotterdam criteria were used. The fasting serum gluco...

Introduction: Lipocalin-2 is abundantly expressed in mature adipocytes and causes insulin resistance. In the physiopathology of PCOS, insulin resistance has great importance. The purpose of this study was to determine serum lipocalin-2 levels in patients with PCOS and to investigate its relationship with body fat percentage, hs-CRP and insulin resistance.Methods and designs: This study was planned as a case controlled study. We enrolled 44 women with PCO...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive period, and it has been considered as a risk factor in cardiovascular disease due to increased prevalence of hypertension, dyslipidaemia, obesity, and insulin resistance. Platelets have a pivotal role in the development of atherothrombosis. Platelet distribution width (PDW) is a marker of platelet size that reflects the heterogeneity of the platelets. This arithmetical inde...

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...

Purpose: This study aims to compare serum urocortin-3 levels in women with PCOS and healthy women, and establish what role urocortin-3 levels play in PCOS.Methods: Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and BMI. Fasting blood glucose (FBG), insulin, hs-CRP, urocortin-3, and free testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance.<p clas...

Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Methods: Ninety wom...